Patty Duke Has Died at Age 69

Patty Duke, an Oscar-winning actress and sitcom star, has sadly died. She was 69-years-old.

The Patty Duke Show star passed away from sepsis caused by a ruptured intestine on Tuesday, March 29, her rep, Mitchell Stubbs, confirmed to ABC News.

Patty winning her Oscar in April 1963.

"She was a wife, a mother, a grandmother, a friend, a mental health advocate and a cultural icon," Stubbs said in a statement. "She will be greatly missed."

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Patty first rose to fame as a child star during the late 1950s. She later won the Best Supporting Actress Academy Award at age 16 for her performance in 1962's The Miracle Worker, a role she previously originated on Broadway.

Patty with her husband, Michael, in August 2004.

From 1963 until 1966, the actress — who was a devoted supporter of educating the public on mental health issues after being diagnosed with bipolar disorder in 1982 — starred on her own sitcom, The Patty Duke Show. She was also known for appearing in movies Billie, (1965), Valley of the Dolls (1967), Me, Natalie (1969) and You'll Like My Mother (1972), among many others.

Patty — who was previously married to Harry Falk, Michael Tell and John Astin — is survived by her husband, Michael Pearce, her three sons, Sean Astin, 45, Mackenzie Astin, 42, and Kevin Pearce, 28, and three granddaughters. Our thoughts are with Patty's family during this difficult time.